S100B is a calcium binding protein, which is secreted from astrocytes. It is a small dimeric cytosolic protein (21 kDa) consisting of ββ or αβ chains. S100B is involved in a variety of intracellular and extracellular regulatory activities.
Over the last decade, S100B has emerged as a candidate peripheral biomarker of blood–brain barrier (BBB) damage and CNS injury. Elevated S100B levels accurately reflect the presence of neuropathological conditions including traumatic head injury and neurodegenerative diseases. Normal S100B levels reliably exclude major CNS pathology. Serum S100B has also been reported as a useful marker for early detection of metastases of melanoma and cerebral complications from head injury, cardiac surgery, and acute stroke.
5H2-3 ~ 22G7-5
22G7-5 ~ 5H2-3
|Purity||>95% as determined by SDS-PAGE.|
|Buffer Formulation||20 mM PB, 150 mM NaCl, 0.1% Proclin 300,pH7.4|
|Storage||Store it under sterile conditions at -20℃ to -80℃ upon receiving.
Recommend to aliquot the protein into smaller quantities for optimal storage.
|Product Name||Cat. No||Clone ID|
Note: Bioantibody can customized quantities per your need.
1. Ostendorp T , Leclerc E , Galichet A , et al. Structural and functional insights into RAGE activation by multimeric S100B[J]. The EMBO Journal, 2007, 26(16):3868-3878.
2. R, D, Rothoerl, et al. High serum S100B levels for trauma patients without head injuries.[J]. Neurosurgery, 2001.