Anti- human IGFBP-1 Antibody, Mouse Monoclonal
Product details
General Information
IGFBP1, also known as IGFBP-1 and insulin-like growth factor-binding protein 1, is a member of the insulin-like growth factor-binding protein family. IGF binding proteins (IGFBPs) are proteins of 24 to 45 kDa. All six IGFBPs share 50% homology and have binding affinities for IGF-I and IGF-II at the same order of magnitude as the ligands have for the IGF-IR. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth-promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. IGFBP1 has an IGFBP domain and a thyroglobulin type-I domain. It binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. The binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
Properties
| Pair Recommendation |
CLIA (Capture-Detection): 4H6-2 ~ 4C2-3 4H6-2 ~ 2H11-1 |
| Purity | >95% as determined by SDS-PAGE. |
| Buffer Formulation | 20 mM PB, 150 mM NaCl, 0.1% Proclin 300,pH7.4 |
| Storage | Store it under sterile conditions at -20℃ to -80℃ upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage. |
Competitive Comparison
| Bioantibody | Clinically Diagnosed Case | Total | |
| Positive | Negative | ||
| Positive | 35 | 0 | 35 |
| Negative | 1 | 87 | 88 |
| Total | 36 | 87 | 123 |
| Specificity | 100% | ||
| Sensitivity | 97% | ||
Order Information
| Product Name | Cat. No | Clone ID |
| IGFBP-1 | AB0028-1 | 4H6-2 |
| AB0028-2 | 4C2-3 | |
| AB0028-3 | 2H11-1 | |
| AB0028-4 | 3G12-11 |
Note: Bioantibody can customized quantities per your need.
Citations
1.Rutanen E M . Insulin-like growth factor binding protein 1: US 1996.
2.Harman, S, Mitchell, et al. Serum Levels of Insulin-Like Growth Factor I (IGF-I), IGF-II, IGF-Binding Protein-3, and Prostate-Specific Antigen as Predictors of Clinical Prostate Cancer[J]. Journal of Clinical Endocrinology & Metabolism, 2000.
