Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined as an essential role in directing the transition from innate to acquired immunity.
1B1-4 ~ 2E4-1
2E4-1 ~ 1B1-4
|Purity||>95%, determined by SDS-PAGE|
|Buffer Formulation||PBS, pH7.4.|
|Storage||Store it under sterile conditions at -20℃ to -80℃ upon receiving.
Recommend to aliquot the protein into smaller quantities for optimal storage.
|Product Name||Cat. No||Clone ID|
Note: Bioantibody can customized quantities per your need.
1.Zhong Z , Darnell Z W , Jr. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6[J]. Science, 1994.
2.J, Bauer, F, et al. Interleukin-6 in clinical medicine[J]. Annals of Hematology, 1991.