Quality Inspection for In Vitro Diagnostic Solutions - Anti-human SHBG Antibody, Mouse Monoclonal – Bioantibody

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General Information
Sex hormone binding globulin (SHBG) is a glycoprotein of about 80-100 kDa; it has a high affinity for 17 beta-hydroxysteroid hormones such as testosterone and estradiol. SHBG
concentration in plasma is regulated by, amongst other things, androgen/estrogen balance, thyroid hormones, insulin and dietary factors. It is the most important transport protein for estrogens and androgens in peripheral blood. SHBG concentration is a major factor regulating their distribution between the protein- bound and free states. Plasma SHBG concentrations are
affected by a number of different diseases, high values being found in hyperthyroidism, hypogonadism, androgen insensitivity and hepatic cirrhosis in men. Low concentrations are found in myxoedema, hyperprolactinaemia and syndromes of excessive androgen activity. Measurement of SHBG is useful in the evaluation of mild disorders of androgen metabolism and enables identification of those women with hirsutism who are more likely to respond to estrogen therapy.

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Citations

1. Selby C. Sex hormone binding globulin: origin, function and clinical significance. Ann Clin Biochem 1990;27:532-541.

2. Pugeat M, Crave JC, Tourniare J, et al. Clinical utility of sex hormone binding globulin measurement. Horm Res 1996;45(3-5):148-155.