Quality Inspection for In Vitro Diagnostic Solutions - Anti-human PGI Antibody, Mouse Monoclonal – Bioantibody

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General Information
Pepsinogen I, the precursors of pepsin, is produced by the gastric mucosa and released into the gastric lumen and peripheral circulation. Pepsinogen consists of a single polypeptide chain of 375 amino acids with an average molecular weight of 42 kD. PG I (isoenzyme 1-5) is secreted mainly by chief cells in the fundic mucosa, whereas PG II (isoenzyme 6-7) is secreted by the pyloric glands and the proximal duodenal mucosa.
Precursor reflects numbers of stomach surface cells as well as glandular cells, and monitors gastric atrophy indirectly. They are also extraordinarily stable because they perform their jobs under the harsh conditions present in the digestive system. The atrophy of the corpus mucosa leads to low synthesis of pepsinogen I and hence its low release into the serum. Serum pepsinogen I indicates function and states of gastric mucosa.

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Citations

1.Sipponen P , Ranta P , Helske T , et al. Serum levels of amidated gastrin-17 and pepsinogen I in atrophic gastritis: an observational case-control study.[J]. Scandinavian Journal of Gastroenterology, 2002, 37(7):785-791.

2.Mangla J C , Schenk E A , Desbaillets L , et al. Pepsin secretion, pepsinogen, and gastrin in Barrett’s esophagus’. Clinical and morphological characteristics[J]. Gastroenterology, 1976, 70(5 PT.1):669-676.