Quality Inspection for In Vitro Diagnostic Solutions - Anti-human IL6, Mouse Monoclonal – Bioantibody

Product details

General Information
Interleukin-6 (IL-6) is a multifunctional α-helical cytokine that regulates cell growth and differentiation of various tissues, which is known particularly for its role in the immune response and acute phase reactions. IL-6 protein is secreted by a variety of cell types including T cells and macrophages as a phosphorylated and variably glycosylated molecule. It exerts actions through its heterodimeric receptor composed of IL-6R that lacks the tyrosine/kinase domain and binds IL-6 with low affinity, and ubiquitously expressed glycoprotein 130 (gp130) that binds the IL-6. IL-6R complex with high affinity and thus transduces signals. IL-6 is also involved in hematopoiesis, bone metabolism, and cancer progression, and has been defined as an essential role in directing the transition from innate to acquired immunity.

Properties

Competitive Comparison

Correlation analysis-<120pg/mL

Correlation analysis -1.5-5000pg/mL

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Note: Bioantibody can customized quantities per your need.

Citations

1.Zhong Z , Darnell Z W , Jr. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6[J]. Science, 1994.

2.J, Bauer, F, et al. Interleukin-6 in clinical medicine[J]. Annals of Hematology, 1991.