Best Price on Brucella Ab - Anti- human PIVKA -II Antibody, Mouse Monoclonal – Bioantibody
Best Price on Brucella Ab - Anti- human PIVKA -II Antibody, Mouse Monoclonal – Bioantibody Detail:
Product details
General Information
Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II), also known as Des-γ-carboxy-prothrombin (DCP), is an abnormal form of prothrombin. Normally, the prothrombin’s 10 glutamic acid residues (Glu) in the γ-carboxyglutamic acid (Gla) domain at positions 6, 7, 14, 16, 19, 20,25, 26, 29 and 32 are γ-carboxylated to Gla by vitamin-K dependent γ- glutamyl carboxylase in the liver and then secreted into plasma. In patients with hepatocellular carcinoma (HCC), γ-carboxylation of prothrombin is impaired so that PIVKA-II is formed instead of prothrombin. PIVKA-II is considered as is an efficient biomarker specific for HCC.
Properties
| Pair Recommendation |
CLIA (Capture-Detection): 1E5-1 ~ 1D6-10 1E5-1 ~ 1E6-7 |
| Purity | >95%, determined by SDS-PAGE |
| Buffer Formulation | 20 mM PB, 150 mM NaCl, 0.1% Proclin 300, pH7.4 |
| Storage | Store it under sterile conditions at -20℃ to -80℃ upon receiving. For long term storage, please aliquot and store it. Avoid repeated freezing and thawing cycles. |
Comparison Analysis
Order Information
| Product Name | Cat. No | Clone ID |
| PIVKA-Ⅱ | AB0009-1 | 1F4-5 |
| AB0009-2 | 1E5-1 | |
| AB0009-3 | 1D6-10 | |
| AB0009-4 | 1E6-7 |
Note: Bioantibody can customized quantities per your need.
Citations
1.Matsueda K , Yamamoto H , Yoshida Y , et al. Hepatoid carcinoma of the pancreas producing protein induced by vitamin K absence or antagonist II (PIVKA-II) and α-fetoprotein (AFP)[J]. Journal of Gastroenterology, 2006, 41(10):1011-1019.
2.Viggiani, Valentina, Palombi,等. Protein induced by vitamin K absence or antagonist-II (PIVKA-II) specifically increased in Italian hepatocellular carcinoma patients.[J]. Scandinavian Journal of Gastroenterology, 2016.
3.Simundic A M . Practical recommendations for statistical analysis and data presentation in Biochemia Medica journal[J]. Biochemia Medica, 2012, 22(1).
4.Tartaglione S , Pecorella I , Zarrillo S R , et al. Protein Induced by Vitamin K Absence II (PIVKA-II) as a potential serological biomarker in pancreatic cancer: a pilot study[J]. Biochemia Medica, 2019, 29(2).
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By Jill from Czech - 2017.07.28 15:46
The company can keep up with the changes in this industry market, product updates fast and the price is cheap, this is our second cooperation, it's good.
By Dominic from Florida - 2018.12.14 15:26
